Nev and Max travelled around the US for five years trying to mend broken hearts, help others get even, and generally having the best TV bromance ever. You’d think by now no-one would dream about trying to fool someone over the internet in fear of these two turning up at their door. But nope, the catfishing era is still going strong, and it’s one of our favourite reality shows. The Story:. Artis thought he was dating a girl named Jess and was prepared to dump his current real-world girlfriend and the mother of his THREE kids for her. The Truth:.
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Because most insects consume plant phenolics daily, they have likely evolved the capacity to detoxify these compounds.
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Plant phenolics are detoxified by prophenoloxidase in the insect gut
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The gut gastrointestinal tract is the long tube that starts at the mouth and ends at the back passage anus. The mouth is the first part of the gut gastrointestinal tract. When we eat, food passes down the gullet oesophagus , into the stomach, and then into the small intestine. The small intestine has three sections – the duodenum, jejunum and ileum. The duodenum is the first part of the small intestine and follows on from the stomach.
The duodenum curls around the pancreas creating a c-shaped tube. The jejunum and ileum make up the rest of the small intestine and are found coiled in the centre of the tummy abdomen.
The digestive system
Before the medical community had better understanding of the mechanisms that cause disease, doctors believed certain ailments could originate from imbalances in the stomach. This was called hypochondriasis. This concept was rejected as science evolved and, for example, we could look under a microscope and see bacteria, parasites, and viruses.
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The digestive system
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Haematopoietic stem cell transplantation HSCT is central to the management of many haematological disorders. A frequent complication of HSCT is acute graft-versus-host disease GVHD , a condition in which immune cells from the donor attack healthy recipient tissues. Acute GVHD of the gastrointestinal tract presents both diagnostic and therapeutic challenges. Although the clinical manifestations are nonspecific and overlap with those of infection and drug toxicity, diagnosis is ultimately based on clinical criteria.
As reliable serum biomarkers have not yet been validated outside of clinical trials, endoscopic and histopathological evaluation continue to be utilized in diagnosis. Once a diagnosis of gastrointestinal acute GVHD is established, therapy with systemic corticosteroids is typically initiated, and non-responders can be treated with a wide range of second-line therapies.
In addition to treating the underlying disease, the management of complications including profuse diarrhoea, severe malnutrition and gastrointestinal bleeding is paramount. In this Review, we discuss strategies for the diagnosis and management of acute GVHD of the gastrointestinal tract as they pertain to the practising gastroenterologist. Haematopoietic stem cell transplantation HSCT is a potentially curative treatment option for patients with haematological malignancies such as leukaemia, lymphoma, myeloma and myelodysplasia and non-malignant diseases such as haemoglobinopathies, aplastic anaemia and immune deficiency syndromes 1.
Before HSCT, patients commonly undergo conditioning therapy, which comprises treatment with preparative chemotherapy to eradicate diseased haematological cells, provide an immuno-suppressed environment for donor cell engraftment and prevent the rejection of haematopoietic progenitor cells from the donor, which are subsequently infused 1. In autologous HSCT, donor cells are obtained from the patient, frozen and infused after conditioning chemo-therapy 2.
Haematopoietic stem cells are most commonly obtained from the bone marrow, peripheral blood or umbilical cord blood 1. The period between conditioning therapy and donor cell engraftment is typically 10—12 days and is marked by profound neutropenia, particularly in the setting of myeloablative conditioning 3. Graft-versus-host disease GVHD occurs when alloreactive T cells from the donor attack healthy tissues in the recipient and arises almost exclusively in patients who have undergone allogeneic HSCT 3.
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Natural gut has been regarded as the premiere tennis string since the early s. It has been, and remains, the most frequently used string on the pro tour. The history of natural gut tennis string dates back almost to the beginning of tennis itself – the first set of natural gut tennis string was manufactured by Pierre Babolat in Seventy-eight years later, VS Brand Gut continues to be one of the most recognized brands of natural gut.
There has been a constant development of synthetic strings since shortly after natural gut found its way into a tennis racquet. With each advancement in technology comes a new string that the manufacturer claims will “play more like gut” than its predecessor. However, for the tennis purist natural gut remains king. Yes, some may argue that natural gut costs more than a multifilament synthetic, but to many players the performance more than justifies the expense.
Contrary to some beliefs, the source of natural gut tennis string is the cow. Well, not the whole cow, just a part of its intestine called the serosa.